Maropitant, commonly known by its brand name Cerenia®, is a neurokinin-1 (NK1) receptor antagonist widely used in veterinary medicine to prevent and treat vomiting and motion sickness in dogs and cats. While Cerenia® is available in standard oral tablets and injectable forms, compounded versions such as oral suspensions and transdermal gels offer significant advantages in terms of administration ease, efficacy, and cost-effectiveness.

Understanding Maropitant and Cerenia®

Maropitant functions by blocking substance P, a neurotransmitter involved in the vomiting reflex, thereby effectively preventing nausea and vomiting in pets. Cerenia®, the commercial formulation of maropitant, is FDA-approved for use in dogs and cats, available in oral tablets and injectable solutions. However, administering standard tablets or injections can be challenging, especially for pets that are uncooperative or have difficulty swallowing pills.

Compounded Maropitant Oral Suspensions

Compounded oral suspensions of maropitant are customized liquid formulations prepared by licensed pharmacists to meet specific needs of individual pets. These suspensions are particularly beneficial for pets that resist taking pills or require precise dosing adjustments. The liquid form allows for easier administration, often flavored to enhance palatability, ensuring pets receive their medication without undue stress.

Compounded Maropitant Transdermal Gels

Transdermal gels are another innovative compounded formulation of maropitant. These gels are applied to the inner pinna (ear flap) of the pet, where the medication is absorbed through the skin into the bloodstream. This method is especially advantageous for cats, which are notoriously difficult to medicate orally. Studies have shown that transdermal administration of maropitant can be an effective alternative to oral or injectable routes, providing comparable therapeutic effects with improved compliance.

Advantages of Compounded Maropitant Formulations

1. Improved Compliance: Customized formulations like oral suspensions and transdermal gels make it easier for pet owners to administer medication, reducing stress for both pets and owners.

2. Tailored Dosing: Compounded medications allow for precise dosing adjustments, catering to the specific weight and health condition of the pet.

3. Enhanced Palatability: Flavoring agents can be added to oral suspensions to make the medication more appealing to pets, increasing the likelihood of successful administration.

4. Cost-Effectiveness: Compounded versions can be more affordable than commercial products, providing a budget-friendly option without compromising efficacy.

Conclusion

Compounded maropitant formulations, such as oral suspensions and transdermal gels, offer significant benefits over standard tablets and injections. They provide easier administration, tailored dosing, and improved compliance, making them a superior choice for managing vomiting and motion sickness in pets. Consulting with a veterinarian and a reputable compounding pharmacy can help determine the most appropriate formulation for your pet's specific needs.