Compounded Maropitant Oral Suspension from PetScript Pharmacy

Compounded Maropitant from PetScript Pharmacy is a highly effective, fast-acting, and non-drowsy prescription medication specifically formulated to prevent or stop episodes of nausea and vomiting in both canine and feline patients. As a customized liquid formulation prepared by licensed compounding pharmacists, it offers significant advantages in managing various forms of emesis (vomiting) and motion sickness.

1. Core Function and Mechanism of Action

The active ingredient in the medication is Maropitant (commonly known by its brand name, Cerenia®). It belongs to a specialized class of antiemetics known as Neurokinin-1 (NK1) receptor antagonists.

• Maropitant works by: Blocking Substance P, a key neuropeptide that serves as a neurotransmitter responsible for initiating the vomiting reflex. This antagonism occurs in both the central nervous system (specifically, the emetic center and the chemoreceptor trigger zone in the brain) and the gastrointestinal tract. By blocking the NK1 receptors, Maropitant effectively neutralizes the primary signal cascade that triggers nausea and vomiting, resulting in its potent antiemetic effects.

• Targeted Action: This targeted action on the central nervous system ensures the medication is a potent solution for treating and preventing vomiting from a wide range of underlying causes, offering superior efficacy compared to medications that only target the stomach.

2. PetScript Pharmacy Compounding Specifications

PetScript Pharmacy prepares customized Maropitant Oral Suspensions designed for easy administration and improved compliance.

• Available Concentrations: PetScript Pharmacy compounds Maropitant in two specific concentrations to allow for precise dosing based on the size and medical needs of the pet:

  • 50 mg/ml Oral Suspension

  • 100 mg/ml Oral Suspension

• Customized Flavors: To enhance palatability, which is crucial for successfully medicating pets, the Compounded Maropitant Oral Suspension is available with a variety of flavors for the pet owner to choose from. This flavoring makes the liquid medication more appealing, ensuring pets receive their full prescribed dose without undue stress.

3. Advantages of Compounded Oral Suspensions

PetScript Pharmacy's compounded oral suspension formulation offers distinct benefits over standard commercial tablets or injections:

4. Indications and Therapeutic Use

Maropitant is FDA-approved for specific uses in dogs and cats and is widely used in veterinary medicine for its potent antiemetic properties:

• Acute Vomiting: Treatment and prevention of acute vomiting episodes caused by various factors, including gastroenteritis, medication side effects, or other illnesses.

• Motion Sickness: Prevention of vomiting associated with travel, commonly referred to as car sickness, in dogs and cats.

• Chemotherapy-Induced Nausea/Vomiting (CINV): Used to alleviate or prevent the severe nausea and emesis associated with certain chemotherapeutic agents.

• Adjunct Analgesic Use: Maropitant may also be utilized during the perioperative period to prevent emesis associated with premedication and as an adjunct treatment for visceral pain, particularly in felines.

5. Administration and Safety Considerations

The compounded oral suspension is typically administered directly into the pet's mouth using a dosing syringe or mixed with a small amount of food.

• Administration Note: When used to prevent motion sickness, the medication is generally administered a minimum of two hours prior to travel, often with a small meal, to allow it to reach maximum efficiency and help prevent stomach upset.

• Prescription Required: Compounded Maropitant is a prescription item and requires professional prescription and approval from a licensed veterinarian before it can be dispensed and shipped. Pet owners are encouraged to consult with their prescriber to determine the appropriate use, dosing, and duration of therapy for their specific animal.