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Home Blog Center Phenylbutazone: Understanding "Bute Paste" and How It Helps Your Pet

Phenylbutazone: Understanding "Bute Paste" and How It Helps Your Pet

Phenylbutazone: Understanding "Bute Paste" and How It Helps Your Pet
PetScript Support
PetScript Support
Nov 28, 2025

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Phenylbutazone: Understanding "Bute Paste" and How It Helps Your Pet

The health and comfort of our animals whether they are companion pets or performance horses is a top priority. When pain and inflammation strike, one of the most recognized and effective medications used by veterinarians is Phenylbutazone, often simply called "bute."

This comprehensive post dives into what Phenylbutazone is, how the oral paste formulation works, and why it is a critical tool for managing pain and improving the quality of life for dogs, cats, and especially horses.


What is Phenylbutazone?

Phenylbutazone is a potent Non-Steroidal Anti-Inflammatory Drug (NSAID). Like common human NSAIDs (such as ibuprofen or naproxen), Phenylbutazone works by inhibiting the production of specific chemicals in the body that cause inflammation, pain, and fever.

In veterinary medicine, Phenylbutazone is a cornerstone for managing acute and chronic pain stemming from musculoskeletal issues.

Key Functions in Animals:

  • Anti-inflammatory: Reduces swelling and inflammation around injured tissue.

  • Analgesic: Provides significant pain relief.

  • Antipyretic: Helps reduce fever (though this is a less common primary use).

Why an Oral Paste? Introducing Phenylbutazone Oral Paste (Bute Paste)

The product listed, Phenylbutazone Oral Paste - 1 gm/5ml - 60 ml, represents a popular and highly practical way to administer this medication, particularly in equine care, but also in some smaller animals.

Concentration Breakdown:

  • 1 gm/5 ml: This tells you the concentration—one gram (1,000 milligrams) of Phenylbutazone is dissolved or suspended in every five milliliters of paste.

  • 60 ml: This is the total volume of the tube or syringe.

The paste format, often delivered via an adjustable oral dosing syringe, offers several key advantages over pills or injections:

  • Ease of Administration (Especially in Horses): It is easy to place the measured dose directly into the animal's mouth.

  • Precise Dosing: The syringe is typically marked to allow for accurate dosage adjustments based on the animal’s weight.

  • Palatability: Compounding pharmacies like PetScript frequently flavor the paste (apple is a popular choice!) to ensure the animal accepts the medication.

The Crucial Role of Bute in Equine Medicine

 

Phenylbutazone is perhaps most famous for its use in horses, where it is vital for managing athletic injuries and chronic conditions.

Common Uses in Horses:

  • Lameness: Routinely used to alleviate the pain and inflammation associated with various causes of lameness, including soft tissue injuries, bruises, and joint issues.

  • Arthritis: Provides relief for horses suffering from chronic degenerative joint diseases.

  • Colic: Used in some cases of non-surgical colic to manage pain and inflammation in the gastrointestinal tract.

  • Post-Operative Pain: An effective component of pain management protocols following surgery.

 Phenylbutazone Use in Dogs and Cats

 

While less common than in horses, Phenylbutazone is also prescribed for smaller companion animals, particularly for short-term, acute pain relief associated with injuries or surgery.

  • Important Note: Phenylbutazone is generally used with greater caution in dogs and cats than in horses. Newer, more selective NSAIDs are often preferred for long-term management of canine and feline arthritis due to potential side effects associated with prolonged use in these species. Always follow your veterinarian's specific instructions for dosing and duration.

A Word of Caution: Safe Use and Monitoring

 

Like all NSAIDs, Phenylbutazone must be used strictly under veterinary guidance. The key to successful pain management with this drug lies in precise dosing and careful monitoring.

Potential Side Effects to Be Aware Of:

  • Gastrointestinal Ulceration: The most common and serious side effect. NSAIDs can interfere with the stomach’s protective lining, leading to irritation, ulcers, and bleeding.

  • Kidney Toxicity: Prolonged or high-dose use can potentially affect kidney function.

If your animal is on Phenylbutazone, your veterinarian may recommend periodic blood work. You should immediately report any signs of concern, such as:

  • Changes in appetite (going off feed).

  • Lethargy or depression.

  • Vomiting or diarrhea.

  • Dark, tarry stools (a sign of internal bleeding/ulceration).

How to Purchase Compounded Phenylbutazone

 

Because Phenylbutazone is a potent medication, it is a prescription-only drug. Compounding pharmacies specialize in making medications easier to administer, safer, and better tailored to an individual animal's needs.

  • You Must Have a Prescription: You will need a valid prescription from your veterinarian.

  • Dosage is Customized: The specific concentration (1 gm/5 ml) and total volume (60 ml) will be specified by your vet based on your animal's weight and condition.

  • Login for Pricing: Pricing often requires you to log in to verify your prescription.

PetScript Pharmacy compounds this trusted anti-inflammatory medication in various strengths and appealing flavors, ensuring your animal gets the highest quality medication with the least amount of fuss.

Ready to order your compounded Phenylbutazone Oral Paste? You will need to Sign in to manage your prescriptions and orders, or you can Request a Quote if you need information on different strengths or flavors.

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This content is intended for counseling purposes only. This content is informational/educational and is not intended to treat or diagnose any disease or patient. No claims are made as to the safety or efficacy of mentioned preparations. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with ProLab Pharmacy. You are encouraged to speak with your prescriber as to the appropriate use of any medication. ProLab Pharmacy’s compounded veterinary preparations are not intended for use in food and food-producing animals. All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them..